March Madness: Michigan State Versus UConn Sweet 16 Odds, Predictions and Picks

(AsiaGameHub) –   Tonight, the No. 3 Michigan State Spartans will face the No. 2 UConn Huskies in the Sweet 16 of the NCAA Tournament. The game is set to begin at 9:45 ET on CBS.

This March Madness matchup is must-see television, featuring legendary coaches Tom Izzo and Danny Hurley battling to advance their teams to the Elite 8.

As of publication, DraftKings lists UConn as a 2.5-point favorite with an over/under of 136.5. Prior to the line shift, there was considerable two-way betting activity at -1.5, with 51% of the spread handle and 52% of the tickets backing UConn.

Best Bet Michigan State vs. UConn: Against the Spread

Spartans +2.5 (-118)

Michigan State (31-5) relies on point guard Jeremy Fears to drive its offense; he tops the country in assists at 9.4 per game. His exceptional playmaking skills were evident in the Spartans’ last contest against Louisville, where he dished out a remarkable 16 assists in their 77-69 victory.

In addition to Fears’ offensive contributions, Michigan State holds a defensive edge. The Spartans are the nation’s best at restricting offensive rebounds, a strength they’ll need to maintain this evening.

UConn’s Tarris Reed (14.2 points per game, 8.9 rebounds per game) and Alex Karaban (13.3 points per game, 5.2 rebounds per game) comprise one of the nation’s top front courts. Notably, Reed grabbed 27 rebounds in their first-round win over Furman and added 13 rebounds in their second-round triumph against UCLA.

UConn (27-7) tends to commit fouls frequently, which could prove decisive in a contest between relatively evenly-matched teams. The Huskies are ranked 239th in the country, averaging 18 fouls per game.

The two squads met in an exhibition match in October, during which Fears converted 10 of 13 free-throw attempts. Overall, Michigan State attempted 44 free throws, making 29 of them.

Michigan State shoots 76.5% from the free-throw line, placing them in the top 40 nationally and providing a clear advantage against a UConn team prone to fouling.

Pick: Michigan State +2.5

Best Player Prop for Michigan State Spartans

Coen Carr OVER 16.5 Points & Rebounds (-104 at FanDuel)

In short, Coen Carr has been sensational throughout March Madness.

That was Coen Carr’s second nice dunk in under a minute https://t.co/KYsJCGRI68

— Michigan State on BTN (@MichiganStOnBTN) March 21, 2026

Carr recorded a double-double in his most recent game against Louisville, tallying 21 points and 10 rebounds. He also surpassed this threshold easily in the opening round against North Dakota State with 17 points and four rebounds.

Back one of the nation’s premier dunkers to deliver another strong performance tonight.

Best Player Prop for UConn Huskies

Alex Karaban OVER 12.5 Points (-125 at FanDuel)

This betting line appears mispriced and ripe for taking advantage of.

Karaban poured in 22 points in the first-round victory over Furman and then dropped 27 against UCLA. Significantly, he took 16 shots in both of those contests. The only other instance where he attempted more shots (18) was in an overtime win versus Providence during the regular season.

Additionally, no other UConn player logs nearly as many minutes as Karaban (33.9 minutes per game). Our recommended wager is on Karaban scoring at least 15 points at DraftKings, where that prop is priced at +125 odds.